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LIFE Health Care Study

Publications 2011

Beutner F, Teupser D, Gielen S, Holdt LM, Scholz M, Boudriot E, Schuler G, Thiery J.
Rationale and Design of the Leipzig (LIFE) Heart Study: Phenotyping and Cardiovascular Patients with Coronary Artery Disease. PloS One 6(12): 1-8
NCBI

Binder H, Fasold M, Hopp L, Cakir V, von Bergen M, Wirth H. 
Molecular phenotypic portraits-exploring te "OMES" with Individual resolution. HIBIT 
PDF

Bocsi J, Mittag A, Pierzchalski A, Osmancik P, Dähnert I, Tarnok A. 
Classification and discrimination of pediatric patients undergoing open heart surgery with and without methylprednisolone treatment by cytomics  Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX. SPIE, Bellingham. ISBN 978-0-8194-8439-0 
SPIE Digital Library 

Böselt I, Tramma D, Kalamitsou S, Niemeyer T, Nykänen P, Gräf, K-J, Krude H, Marenzi KS, Di Candia S, Schöneberg T, Schulz A. 
Functional characterization of novel loss-of-function mutations in the vasopressin type 2 receptor gene causing nephrogenic diabetes insipidus. Nephrol Dial Transpl 0: 1-8
OxfordJournals

Buck D, Cepok S, Hoffmann S, Grummel V, Joachim A, Berthele A, Hartung H-P, Wassmuth R, Hemmer, B.
Influence of the HLA-DRB1 Genotype on Antibody Development to Interferon Beta in Multiple Sclerosis.  Arch Neorol 68 (4): 480-487
ArchNeurol

Burkhardt R, Breslow J L.
TRIBI, chromosome 8 and the regulation of blood lipids. Clin Lipidol 6(2): 119-122
FutureMedicine

Burkhardt R, Sündermann N, Ludwig D, Ceglarek U, Holdt LM, Tiery J, Teupser D.
Cosegregation of Aortic Root Atherosclerosis and Intermediate Lipid Phenotypes on Chromosomes 2 and 8 in an Intercross of C57BL/6 and BALBc/ByJ Low-Density Lipoprotein Receptor -/- Mice. Arterioscler Thromb Vasc Biol 31: 775-784
AmHeartAssoc

Dukart J, Schroeter ML, Mueller K.,The Alzheimer's Diseases neuroimaging Initiative.
Age Correction in Dementia – Matching to a Healthy Brain. Plos One 6(7): 1-9
NCBI

Ehreke L, Luck T, Luppa M, König HH, Villringer A, Riedel-Heller SG. 
Clock Drawing Test - screening utility for mild cognitive impairment according to different scoring systems: results of the Leipzig Longitudinal Study of the Aged (LEILA 75+). Int Psychogeriatr 23(10): 1592-1601
Cambridge Journals/International PsychogeriatricsPubMed

Ehreke L, Luppa M, König HH, Villringer A, Riedel-Heller SG. 
Does the Clock Drawing Test Predict Dementia? Results of the Leipzig Longitudinal Study of the Aged (LEILA 75+). Dement Geriatr Cogn Disord 31: 89-97
PubMedKarger

Eibisch M, Fuchs B, Schiller J, Süß R, Teuber K.
Analysis of Phospholipid Mixtures from Biological Tissues by Matrix-Assisted Laser Desorption and Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS): A Laboratory Experiment. J Chem Educ 88(4): 503-507
Journal of Chemical Education

Engel KMY, Schrök K, Teupser D, Holdt LM, Tönjes A, Kern M, Dietrich K, Kovacs P, Krügel U, Scheidt HA, Schiller J, Huster D, Brockmann GA, Augustin M, 
Thiery J, Blüher M, Stumvoll M, Schöneberg T, Schulz A.

Reduced food intake and body wheigt in mice deficent for the G protein-coupled receptor GPR82. PlosONE 6(12) doi: 10.1371/journal.pone.0029400
PlosOne

Fasold M, Langenberger D, Binder H, Stadler PF, Hoffmann S.
DARIO: A ncRNA detection and analysis tool for next-generation sequencing experiments. Nucl Acid Res doi:10.1093/nar/gkr35
Oxford Journals, Nucleic Acids Research

Findeiss S, Langenberger D, Stadler PF, Hoffmann S. 
races of Post-Transcriptional RNA Modifications in Deep Sequencing Data. Biol Chem 392(4): 305-313
PubMedde Gryter Reference Global

Fuchs B, Süß R, Teuber K, Eibisch M, Schiller J. 
Lipid analysis by thin-layerchromatography —A review of the current state. J Chromatogr A 1218(19): 2754-2774
PubMedScienceDirect

Gielen S, Sandri M, Erbs S, Adams V.
Exercise-induced Modulation of Endothelial Nitric Oxide Production. Curr Pharm Biotechno 12(9): 1375-1384
BethamDirect

Gross A,Tonjes A, Kovacs P, Veeramah KR, Ahnert P, Roshyara NR, Gieger C, Rueckert IM, Loeffler M, Stoneking M, Wichmann HE, Novembre J, Stumvoll M, Scholz M. 
Population-genetic comparison of the Sorbian isolate population in Germany with the German KORA population using genome-wide SNP arrays. BMC Genet 12: 67
BMC Genetics

Hiemisch A, Kiess W, Brähler E. 
Mental job strain in a university children's hospital-a study on stress experience and the resulting employee health. Klin Padiatr  233(4): 236-241
NCBI

Hoffmann S. 
Computational Analysis of High Throughput Sequencing Data  Bioinformatics for Omics Data : Methods and Protocols. 719: 199-217
PubMedSpringerLink

Holland H, Mocker K, Ahnert P, Kirsten H, Hantmann H, Koschny R, Bauer M, Schober R, Scholz M, Meixensberger J, Krupp W. 
High resolution genomic profiling and classical cytogenetics in a group of benign and atypical meningiomas. Cancer Genet 204(10):541-549
elsevier

Kiess W, Sergejev E, Körner A, Hebebrand J. 
Is it possible to treat obesity in children and adolescents? 
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz  54: 527-532
NCBI

Kirsten T, Gross A, Hartung M, Kolb L, Rahm E. 
GOMMA: A Component-based Infrastructure for managing and analyzing Life Science Ontologies and their Evolution.  J Biomed Semantics 2: 6
Journal Of Biomedical Semantics

Kirsten H, Wilcke A, Ligges C, Boltze J, Ahnert P. 
Association study of a functional genetic variant in KIAA0319 in German dyslexics.Psychiat Genet (Epub ahead of print) 2012 22(4):216-7
NCBI

Langenberger D,  Bartschat S, Hertel J, Hoffmann S, Tafer H, Stadler PF. 
MicroRNA or Not MicroRNA? Lecture Notes in Computer Science 
Volume 6832/2011, 1-9.
SpringerLink

Langenberger D, Pundhir S, Ekstrøm CT, Stadler PF, Hoffmann S, Gorodkin J. 
deepBlockAlign: A tool for aligning RNA-seq profiles of read block patterns. Bioinformatics 28(1): 17-24 
Bioinformatics

Luck T, Luppa M, Angermeyer CM, Villringer A, König HH, Riedel-Heller SG.
Impact of impairment in instrumental activities of daily living and mild cognitive impairment on time to incident dementia: results of the leipzig longitudinal study of the aged. Psychol Med 41: 1087-1097
NCBI

Luppa M, Gentzsch K, Angermeyer MC, Weyerer S, König HH, Riedel-Heller SG. 
Geschlechtsspezifische Prädiktoren von Institutionalisierung im Alter – Ergebnisse der Leipziger Längsschnittstudie in der Altenbevölkerung (LEILA 75+). Psychiat Praxis 38: 185-189
Thieme

Olbrich S, Sander C, Matschinger H, Mergel R, Trenner M, Schönknecht P, Hegerl U. 
Brain and body: Associations between EEG-vigilance and the autonomous nervous system during rest. J Psychophysiol 25(4): 190-200
APAPsycNet

Otto C, Hoffmann S, Gorodkin J, Stadler PF.
Fast local fragment chaining using sum-of-pair gap costs. Algorithms Mol Biol 6:4
PubMed

Sacher J, Neumann J, Fünfstück Tillmann, Solimann A, Villringer A, Schroeter ML. 
Mapping the depressed brain: A meta-analysis of structural and functional alterations in major depressive disorder. J Affect Disord 2011 (Epub 2011 Sep 3) 2012: 140(2): 142-148
NCBI

Schmidtke C, Findeiß S, Sharma CM, Kuhfuß J, Hoffmann S, Vogel J, Stadler PF, Bona U. 
Genome-wide transcriptome analysis of the plant pathogen Xanthomonas identifies sRNAs with putative virulence functions. Nucl Acid Res (Epub 2011 Nov 12) 2012: 40(5): 2020-2031
NCBI

Scholz M, Engert A, Franklin J, Josting A, Diehl V, Hasenclever D, Loeffler M. 
Impact of first- and second-line treatment for Hodgkin’s lymphoma on incidence of AML/MDS and NHL-experience of German Hodgkin’s Lymphoma Study Group analysed by a parametric model of carcinogenesis. Ann Oncol 22(3): 681-687
PubMedOxford Journals

Scholz M, Kirsten H. 
Comparison of scoring methods for the detection of causal genes with or without rare variants. BMC Proceedings 5(9):49 
NCBI

Schonhoff P, Körner A, Kratzsch J, Pfäffle R, Kiess W.  
Long Term Clinical Management of Girls with Turner Syndrome at a Center of Pediatric Endocrinology Exp Clin Endocrinol. Diabetes 119(69): 327-333
NCBI

Schroeter ML, Neumann J. 
Combined imaging markers dissociate Alzheimer’s disease and frontotemporal lobar degeneration – an ALE meta‑analysis. Front Aging Neurosci 3:10 doi: 10.3389/fnagi.2011.00010
PubMedCentral

Schroeter ML, Vogt B, Frisch S, Becker G, Barthel H, Mueller K, Villringer A, Sabri O. 
Executive deficits are related to the inferior frontal junction in early dementia. Brain 135: 201-215
PubMedCentral

Schroeter ML, Vogt B, Frisch S, Becker G, Seese A, Barthel H, Mueller K, Villringer A, Sabri O. 
Dissociating behavioral disorders in early dementia—An FDG-PET study. Psychiat Res  194: 235-244
NCBI

Schuster S, Hechler C, Gebauer C, Kies W, Kratzsch J.
Leptin in maternal serum and breast milk: association with infants' body weight gain in a longitudinal study over 6 months of lactation. Pediatrr Res 70(6): 663-7
NCBI

Teuber K, Schiller J, Jacob U, Lüpold S, Orledge JM, Blount JD, Royle NJ, Hoodless A, Müller K.
MALDI-TOF mass spectrometry as a simple tool to determine the phospholipid/glycolipid composition of sperm - Pheasant spermatozoa as one selected example. Animal Reprod Science 123: 270-278
PubMedScienceDirect

Teupser D, Weber O, Nageswara Rao T, Sass K, Thiery J, Fehling HJ. 
No reduction of Atherosclerosis in C-reactive protein (CRP)-deficient mice. J Biol Chem 286(8): 6272-6279
PubMedThe Journal of Biological Chemistry

Veeramah KR, Tönjes A, Kovacs P, Gross A, Wegmann D, Geary P, Gasperikova D, Klimes I, Scholz M, Novembre J, Stumvoll M. 
Genetic variation in the Sorbs of eastern Germany in the context of broader European genetic diversity. Eur J Hum Genet 19(9): 995-1001
NCBI

Wagner IV, Sabin MA, Pfäffle RW, Hiemisch A, Sergejev E, Körner A, Kiess W. 
Effects of obesity on human sexual development. Nat Rev Endocrinol doi: 10.1038/nrendo.2011.241 
NCBI

Wilke A, Ligges C, Burkhardt J, Alexander M, Wolf Ch, Quente E, Ahnert P, Hoffmann P, Becker A, Müller-Myhsok B, Cichon S, Boltze J, Kirsten H.
Imaging genetics of FOXP2 in dyslexia Eur J Hum Genet 20(2):224-229
European Journal of Human GeneticsPubMed

Wirth H, Loeffler M, von Bergen M, Binder H. 
Expression cartography of human tissues using self organizing maps. BMC Bioindformatics 12: 306
BioMed Central

Wu J, Teuber K, Eibisch M, Fuchs B, Schiller J. 
Chlorinated and brominated phospholipids are generated under the influence of the Fenton reagent - A MALDI-TOF MS study Chem Phys Lipids. 164(1): 1-8
PubMedScienceDirect

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