LIFE Health Care Study

Publications 2012

Becker S, Kortz L, Helmschrodt C, Thiery J, Ceglarek U.
LC-MS-based metabolomics in the clinical laboratory. J Chromatogr B Analyt Technol Biomed Life Sci. 883-884:68-75 (Epub 2011 Okt 22)

Beutner F, Brendel D, Teupser D, Sass K, Mueller M, Ceglarek U, Thiery J.
Effect of everolimus on pre-existing atherosclerosis in LDL-receptor deficient mice. Atherosclerosis 222(2): 337-343 (Epub 2012 Mar 10)

Beutner F, Teren A, Gielen S, Schuler G, Wirkner K, Tiller D, Loeffler M, Scholz M. 
Automated photoplethysmography-based determination of ankle-brachial index: a validation study against Doppler sonography. Clin Res Cardiol. 101(11): 875-838

Breitfeld J, Tönjes A, Böttcher Y, Schleinitz D, Wiele N, Marzi C, Brockhaus C, Rathmann W, Huth C, Grallert H, Illig T, Blüher M, Kovacs P, Stumvoll M. 
Genetic Variation in the Vaspin Gene Affects Circulating Serum Vaspin Concentrations. Int J Obesity 37(6): 861-866 (Epub 2012 Aug 21)

Buchwald U, Teupser D, Kuehnel F, Grohmann J, Schmieder N, Beindorff N, Schlumbohm C, Fuhrmann H, Einspanier A.
Prenatal stress programs lipid metabolism enhancing cardiovascular risk in the female F1, F2 and F3 generation in the primate model common marmoset (Callithrix jacchus). J Med Primatol (41) 231-240

Burkhardt J, Kirsten H, Holland H, Krupp W, Ligges C, Quente E, Boltze J, Ahnert P, Wilcke A. 
Association of rs2069459 in the CDK5 gene with dyslexia in a German cohort. Psychiatr Genet 22 (6): 307-308

Burkhardt J, Kirsten H, Wolfram G, Quente E, Ahnert P. 
Differential allelic expression of IL13 and CSF2 genes associated with asthma. Genet Mol Biol 35(3) 367-574

Doehnert M, Brandeis D, Schneider G, Drechsler R, Steinhausen HC. 
A neurophysiological marker of impaired preparation in an 11-year follow-up study of attention-deficit/hyperactivity disorder (ADHD). J Child Psychol Psychiatry 54(3): 260-270 (Epub 2012 Jul 13)

Doehnert M, Brandeis D, Schneider G, Drechsler R, Steinhausen HC. 
Attenuated contingent negative variation (CNV) as a persistent electrophysiological marker of impaired preparation in an 11-year follow-up study of ADHD. Clin Res Cardiol DOI 10.1007/s00392-012-0471-z

Doose G, Metzler D.
Bayesian sampling of evolutionarily conserved RNA secondary structures with pseudoknots. Bioinformatics 28(17) 2242-2248

Dukart J, Mueller K, Barthel H, Villringer A, Sabri O, Schroeter L, and the Alzheimer's Disease Neuroimaging Initiative.
Meta-analysis-based SVM classification enables accurate detection of Alzheimer's disease across different clinical centers using FDG-PET and MRI. Psychiat Res Neuroim (Epub 2012 Nov 10) 2013 212(3):230-206

Fasold M, Binder H. 
Estimating RNA-quality unsing Genechip microarrays. BMC Genomics. 13:186. doi: 10.1186/1471-2164-13-186

Fasold M, Binder H. 
AffyRNADegradation: Control and correction of RNA quality effects in GeneChip expression data. Bioinformatics (Epub 2012 Okt 24) 2013 29(1):129-131

Fischer J, Böhm S, Scholz M, Müller T, Witt H, George J, Sarrazin C, Susser S, Schott E, Suppiah V, Booth D, Stewart G, van Bömmel F, Brodzinski A, Fülöp B, Migaud P, Berg T. 
Combined effects of different IL28B gene variants on the outcome of dual combination therapy in chronic HCV type 1 infection Hepatology. 55(6):1700-10. doi: 10.1002/hep.25582

Glauche I, Horn K, Horn M, Thielecke L, Essers MA, Trumpp A, Roeder I.
Therapy of chronic myeloid leukaemia can benefit from the activation of stem cells: simulation studies of different treatment combinations. Br J Cancer 106(11):1742-52

Gross A, Ziepert M, Scholz M.
KMWin - A Convenient Tool for Graphical Presentation of Results from Kaplan-Meier Survival Time Analysis. PlosONE 6(7) e38960

Hegerl U, Hensch T. 
The vigilance regulation model of affective disorders and ADHA. Neurosci Biobehav (Epub ahead of print) doi: 10.1016/j.neubiorev.2012.10.008

Hertel J, Bartschat S, Wintsche A, Otto C, Of The Bioinformatics Computer Lab TS, Stadler PF.
Evolution of the let-7 microRNA Family.  RNA Biol. 9:(3): 231-241

Holdt LM, Teupser D. 
Recent studies of the human chromosome 9p21 locus, which is associated with atherosclerosis in human populations. Arterioscler Thromb Vasc Biol 32: 196-206

Holiga S, Möller HE, Sieger T, Schroeter M, Jech R, Mueller K.
Accounting for movement increases sensitivity in detecting brain activity in Parkinson's disease. PlosONE e36271

Holland H, Ahnert P, Koschny R, Kirsten H, Bauer M, Schober R, Meixensberger J, Fritzsch D, Krupp W.
Detection of novel genomic aberrations in anaplastic astrocytomas by GTG-banding, SKY, locus-specific FISH, and high density SNP-array. Pathol Res Pract 208(6) 325-330

Kuehnel F, Buchwald U, Grohmann J, Teupser D, Einspanier A.
Parameters of haematology, clinical chemistry and lipid metabolism in the common marmoset and alterations under stress conditions. J Med Primatol 4(41)

Luck T, Luppa M, Riedel-Heller SG.
Epidemiology of dementia – A current overview. Public Health Forum 76 11e1-11e3

Luck T, Luppa M, Sieber J, Schomerus G, Werner P, König HH, Riedel-Heller SG.
Attitudes of the German general population toward early diagnosis of dementia – Results of a representative telephone survey. PLoS ONE 7(11): e50792.

Luck T, Luppa M, Wiese B, Maier W, van den Bussche H, Eisele M, Jessen F, Weeg D, Weyerer S, Pentzek M, Leicht H, Koehler M, Tebarth F, Olbrich J, Eifflaender-Gorfer S, Fuchs A, Koenig HH, Riedel-Heller SG.
Prediction of Incident Dementia: Impact of Impairment in Instrumental Activities of Daily Living and Mild Cognitive Impairment – Results from the German Study on Ageing, Cognition and Dementia in Primary Care Patients. Am J Geriatr Psychiatry (Epub ahead of print)

Luppa M, Luck T, König HH, Angermeyer MC, Riedel-Heller SG. 
Natural course of depressive symptoms in late life. An 8-year population-based prospective study. J Affect Disord. 142(1-3) 166-71

Luppa M, Sikorski C, Luck T, Weyerer S, Villringer A, König HH, Riedel-Heller SG. 
Prevalence and risk factors of depressive symptoms in latest life--results of the Leipzig Longitudinal Study of the Aged (LEILA 75+). Int J Geriatr Psychiatry. 27(3):286-95.

Milic I, Federova M, Teuber I, Schiller J, Hoffmann R. 
Characterization of oxidation products 1-palmitoyl-2-linoleoyl-sn-glycerophosphatidylcholine in aqueous solutions Q2 and their reactions with cysteine, histidine and lysine Q3 residues. Chem Phys Lipids 165(2): 186-196 

Mueller K, Sacher J, Arelin K, Holiga S, Kratzsch J, Villringer A, Schroeter ML. 
Overweight & obesity are associated with neuronal injury in the human cerebellum & hippocampus in young adults: A combined MRI, serum marker and gene expression study. Translational Psychiatry 2 e200

Mütze U, Beblo S, Kortz L, Glaser C, Brügel M, Rohde C, Thiery J, Kiess W, Ceglarek U.
Metabolomics of Dietary Fatty Acid Restriction in Patients with Phenlyketonuria. PlosONE 7(8) e43021

Mukherjee C, Koch E, Banusch J, Scholz M, Kaisers UX, Ender J.
Intrathecal morphine is superior to intravenous PCA in patients undergoing minimally invasive cardiac surgery. Ann Card Anaesth 15(2) 122-127 
Annals in

Olbrich S, Sander C, Minkwitz J, Chittka T, Mergl R, Hegerl U, Himmerich H. 
EEG Vigilance Regulation Patterns and Their Discriminative Power to Separate Patients with Major Depression from Healthy Controls. Neuropsychobiology 65: 188-194

Otto C, Reiche K, Hackermüller J. 
Detection of differentially expressed segments in tiling array data.  Bioinformatics  28:(11) 1471-1479

Otto C, Stadler FP, Hoffmann S. 
Fast and sensitive mapping of bisulfite-treated sequencing data. Bioinformatics 28: (13) 1698-170

Quante M, Hesse M, Döhnert M, Fuchs M, Hirsch C, Sergeyev E, Casprzig N, Geserick M, naumann s, Koch C, Sabin MA, Hiemisch A, Körner A, Kiess W. 
The LIFE child study: a life course approach to disease and health. BMC Public Health

Quinque EM, Arelin K, Dukart J, Roggenhofer E, Streitbürger DP, Villringer A, Frisch S, Mueller K, Schroeter ML. 
Identifying the neural correlates of executive functions in early cerebral microangiopathy: a combined VBM and DTI study. J Cerebr Blood F Met 32(10): 1869-1878

Richter J, Schlesner M, Hoffmann S, Kreuz M, Leich E, Burkhardt B, Rosolowski M, Ammerpohl O, Wagener R, Bernhart SH, Lenze D, Szczepanowski M, Paulsen M, Lipinski S, Russell RB, Adam-Klages S, Apic G, Claviez A, Hasenclever D, Hovestadt V, Hornig N, Korbel JO, Kube D, Langenberger D, Lawerenz C, Lisfeld J, Meyer K, Picelli S, Pischimarov J, Radlwimmer B, Rausch T, Rohde M, Schilhabel M, Scholtysik R, Spang R, Trautmann H, Zenz T, Borkhardt A, Drexler HG, Möller P, MacLeod RA, Pott C, Schreiber S, Trümper L, Loeffler M, Stadler PF, Lichter P, Eils R, Küppers R, Hummel M, Klapper W, Rosenstiel P, Rosenwald A, Brors B, Siebert R; ICGC MMML-Seq Project.
Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing. Nat Genet 44(12) 1316-1320 

Richter M, Bishop CA, Dukart J, Stuehler E, Mueller K, Schroeter ML, Merhof D.
Skeleton-based gyri sulci separation for improved assessment of cortical thickness. IEEE-ISBI conference proceedings

Ritscher L, Engemaier E, Stäubert C, Liebscher I, Schmidt P, Hermsdorf T, Römpler H, Schulz A, Schöneberg T. 
The ligand specificity of the G-protein-coupled receptor GPR34. Biochem J. 443(3): 841-850

Rohlf T, Steiner L, Przybilla J, Prohaska S, Binder H, Galle J.
Modeling the dynamic epigenome: from histone modifications towards self-organizing chromatin. Epigenomics 4(2) 205-219

Roling G, Sesselmann Y, Fleischer S, Beutner K, Behrens J, Luck T, Luppa M, Riedel-Heller SG.
Handlungsanleitung für die Durchführung Präventiver Hausbesuche. Hallesche Beiträge zu den Gesundheits- und Pflegewissenschaften 11 (2)
Uni Halle

Saalbach A, Vester K, Rall K, Tremel J, Anderegg U, Beck-Sickinger AG, Blüher M, Simon JC.
Vaspin - a link of obisity and psoriasis. Exp Dermatol. 309-312

Scholz M, Schirm S, Wetzler M, Engel C, Loeffler M.
Pharmacokinetic and -dynamic modelling of G-CSF derivatives in humans doi: 10.1186/1742-4682-9-32

Schroeter ML.
Considering the frontomedian cortex in revised criteria for behavioural variant frontotemporal dementia. Brain  (in prep. for online publication)

Steiner L, Hopp L, H. Wirth, Galle J, Binder H, Prohaska S J , Rohlf T. 
A Global Genome Segmentation Method for Exploration of Epigenetic Patterns. PlosONE, 7(10) e46811

Streitbürger DP, Arelin K, Kratzsch J, Thiery J, Steiner J, Villringer A, Mueller K, Schroeter M. 
Validating serum S100B and neuron-specific enolase as biomarkers for the human brain- a combined serum, gene expression and MRI study. PlosONE 7(8) e43284

Teuber K, Federova M, Teuber I, Hoffmann R, Schiller J.
2,4-Dinitrophenylhydrazine as a new reactive matrix to analyze oxidized phospholipids by MALDI-TOF mass spectrometry. Anal Lett 45 1-9
Taylor&Francis Online

Wirth H, von Bergen M, Binder H.
Mining SOM expression portraits: Feature selection and integrating concepts of molecular function. BioData Min 5 (1): 18
BioData Min

Wirth H, v Bergen M, Murugaiyan J, Rösler U, Stokowsky T, Binder H.
MALDI-typing of infectious algae of the genus Prototheca using SOM portraits. J Microbiol Meth 88(1): 83-97

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