LIFE Health Study

Publications 2014

Annibal A, Schubert K, Wagner U, Hoffmann R, Schiller J, Fedorova M.
New covalent modifications of phosphatidylethanolamine by alkanals: mass spectrometry based structural characterization and biological effects. J Mass Spectrom 49(7): 557-569 doi: 1010.1002/jms.3373

Benyamin B, Esko T, Ried JS, Radhakrishnan A, Vermeulen SH, Traglia M, Gögele M, Anderson D, Broer L, Podmore C, Luan J, Kutalik Z, Sanna S, van der Meer P, Tanaka T, Wang F, Westra HJ, Franke L, Mihailov E, Milani L, Häldin J, Winkelmann J, Meitinger T, Thiery J … et al.
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis. Nat Commun. 5:4926. doi: 10.1038/ncomms5926

Beutner F, Ubrich R, Zachariae S, Engel C, Sandri M, Teren A, Gielen S. 
Validation of a brief step-test protocol for estimation of peak oxygen uptake. Eur J Prev Cardiol (Epub ahead of print)

Binder H, Wirth H.
Analysis of large-scale OMIC data using Self Organizing Maps. Encyclopedia of Information Science and Technology Third Edition, M. Khosrow-Pour, Editor. IGI global. 1642-1654.

Bocsi J, Melzer S, Dähnert I, Tárnok A.
OMIP-023: 10-Color, 13 antibody panel for in-depth phenotyping of human peripheral blood leukocytes. Cytometry A 85(9):781-784. doi: 10.1002/cyto.a.22505

Cakir V, Wirth H, Hopp L, Binder H.
miRNA expression landscapes in stem cells, tissue and cancer. Meth Mol Biol 1107: 279-302

Ceglarek U, Dittrich J, Helmschrodt C, Wagner K, Nofer JR, Thiery J, Becker S.
Preanalytical Standardization of Sphingosine-1-Phosphate, Sphinganine-1-Phosphate and Sphingosine Analysis in Human Plasma by Liquid Chromatography – Tandem Mass Spectrometry. Clin Chim Acta 435: 1-6

Derikx MH, Monique H, Kovacs P, Scholz M, Masson E, Chen JM, Ruffert C et al.. 
Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study. Gut. DOI: 10.1136/gutjnl-2014-307453.

Dittrich J, Becker S, Hecht M, Ceglarek U. 
Sample Preparation Strategies for Targeted Proteomics via Proteotypic Peptides in Human Blood using Liquid Chromatography Tandem Mass Spectrometry. Proteom Clin Appl DOI:10.1002/prca.201400121 (Epub ahead of print) 

Gaede-Illig C, Zachariae S, Menzel C, Alfermann D.
Körperliche Aktivitat erfassen – ein Vergleich vom IPAQ-SF und dem SenseWear Pro Armband. Dtsch Z Sportmed 65: 154 – 159 doi: 10.5960/dzsm.2014.130

Gasch M, Goroll T, Bauer M, Hinz D, Schütze N, Polte T, Kesper D, Simon J C, Hackermüller J, Lehmann I, Herberth G.
Generation of IL-8 and IL-9 Producing CD4+ T Cells Is Affected by Th17 Polarizing Conditions and AHR Ligands. Hindawi doi.org/10.1155/2014/182549

Geissler J, Romanos M, Hegerl U, Hensch T.
Hyperactivity and sensation seeking as autoregulatory attempts to stabilize brain arousal in ADHD and mania? (Epub ahead of print)

Gross A, Schirm S, Scholz, M. 
Ycasd - a tool for capturing and scaling data from graphical representations. BMC Bioinformatics 15: 219. DOI: 10.1186/1471-2105-15-219

Hackermüller J, Reiche K, Otto C, Hösler N, Blumert C, Brocke-Heidrich K, et al. 
Cell cycle, oncogenic and tumor suppressor pathways regulate numerous long and macro non-protein coding RNAs. Genome Biol. 15(3): R48. DOI: 10.1186/gb-2014-15-3-r48.

Häntzsch M, Tolios A, Beutner F, Nagel D, Thiery J, Teupser D, Holdt LM.
Comparison of Whole Blood RNA Preservation Tubes and Novel Generation RNA Extraction Kits for Analysis of mRNA and MiRNA Profiles. PloS One 9(12) e113298 DOI 10.1371/journal.pone.0113298

Hoffmann S, Otto C, Doose G, Tanzer A, Langenberger D, Christ S, Kunz M, Holdt L, Teupser D, Hackermüller J, Stadler PF.
A multi-split mapping algorithm for circular RNA, splicing, trans-splicing, and fusion detection. Genome Biology 15(2)R34

Kortz L, Dorow J, Ceglarek U.
Liquid chromatography-tandem mass spectrometry for the analysis of eicosanoids and related lipids in human biological matrices: A review. J Chromatogr B doi: 10.1016/j.jchromb.2014.01.046

Luck T, Luppa M, Matschinger H, Jessen F, Angermeyer MC, Riedel-Heller SG. 
Incident subjective memory complaints and the risk of subsequent dementia. Acta Psychiatrica Scandinavica 2014 Sep 9 [Epub ahead of print].

Luck T, Then FS, Luppa M, Schroeter ML, Arélin K, Burkhardt R, Thiery J, Löffler M, Villringer A, Riedel-Heller SG.
Association of the Apolipoprotein E Genotype With Memory Performance and Executive Functioning in Cognitively Intact Elderly. Neuropsychology 2014 Nov 3 (epub ahead of print)

Mueller B, Ahnert P, Burkhardt J, Brauer J, Czepezauer I, Quente E, et al. 
Genetic risk variants for dyslexia on chromosome 18 in a German cohort. Genes Brain Behav. 13(3) 350 – 356. DOI: 10.1111/gbb.12118.

Otto C, Stadler PF, Hoffmann S.
Lacking alignments? The next generation sequencing mapper segemehl revisited. Bioinformatics (Epub ahead of print)

Polyakova M, Stuke K, Schuemberg K, Mueller K, Schoenknecht P, Schroeter ML. 
BDNF as a biomarker for successful treatment of mood disorders: A systematic & quantitative meta-analysis. J Affect Disord (in press)

Quante M, Bruckmann S, Wallborn T, Wolf N, Sergeyev E, Adler M, Hesse M, Geserick M, Naumann S, Koch C, Nivarthi H, Engel C, Körner A, Kiess W, Hiemisch A.
Managing incidental findings and disclosure of results in a paediatric research cohort-the LIFE Child study cohort. J Pediatr Endocrinol Metab. doi: 10.1515/jpem-2014-0079 (Epub ahead of print)
de gryter

Quinque EM, Karger S, Arelin K, Schroeter ML, Kratzsch J, Villringer A. 
Structural and func-tional MRI study of the brain, cognition and mood in long-term adequately treated Hash-imoto's thyroiditis. Psychoneuroendocrinology 42 188 - 98.

Rivarola-Duarte L, Otto C, Jühling F, Schreiber S, Bedulina D, Jakob L, Gurkov A, Axenov-Gribanov D, Sahyoun AH, Lucassen M, Hackermüller J, Hoffmann S, Sartoris F, Pörtner HO, Timofeyev M, Luckenbach T, Stadler PF. 
A first glimpse at the genome of the Baikalian amphipod Eulimnogammarus verrucosus. J Exp Zool B Mol Dev Evol 322(3): 177-189 DOI 10.1002/jez.b.22560

Roshyara NR, Kirsten H, Horn K, Ahnert P, Scholz M. 
Impact of pre-imputation SNP-filtering on genotype imputation results. BMC Genet. 15(1) 88. DOI: 10.1186/s12863-014-0088-5.

Roshyara NR, Scholz M. 
fcGENE: a versatile tool for processing and transforming SNP datasets. PLoS One (7) e97589. DOI: 10.1371/journal.pone.0097589.

Schaefer A, Quinque EM, Kipping JA, Arélin K, Roggenhofer E, Frisch S, Villringer A, Mueller K, Schroeter ML.
Early small vessel disease affects fronto-parietal and cerebellar hubs in close correlation with clinical symptoms – A resting-state fMRI study. J Cereb Blood Flow Metab 34(7) 1091-1095

Schirm S, Engel C, Loeffler M, Scholz M. 
A combined model of human erythropoiesis and granulopoiesis under growth factor and chemotherapy treatment. Theor Biol Med Model 11: 24 DOI: 10.1186/1742-4682-11-24.

Schroeter ML, Bzdok D, Eickhoff SB, Neumann J. 
Frontomedian cortex is central for moral deficits in behavioural variant frontotemporal dementia. J Neurol Neurosurg Psychiatry (in press)

Schroeter ML, Laird AR, Chwiesko C, Deuschl C, Schneider E, Bzdok D, Eickhoff SB, Neumann J. 
Conceptualizing neuropsychiatric diseases with multimodal data-driven meta-analyses – The case of behavioral variant frontotemporal dementia. Cortex 57: 22 - 37.

Schroeter ML, Mueller K, Arelin K, Sacher J, Holiga S, Kratzsch J, Luck T, Riedel-Heller S, Villringer A.
Serum neuron-specific enolase is related to cerebellar connectivity - A resting-state fMRI pilot study. J Neurotrauma. (Epub ahead of print) doi:10.1089/neu.2013.3163

Schroeter ML, Steiner J, Schoenknecht P, Mueller K. 
Further evidence for a role of S100B in mood disorders: A human gene expression mega-analysis. J Psychiatr Res 53: 84-86.

Seidler A, Thinschmidt M, Deckert S, Then FS, Hegewald J, Nieuwenhuijsen K, Riedel-Heller SG. 
The role of psychosocial working conditions on burnout and its core component emo-tional exhaustion - a systematic review. J Occup Med Toxicol 9(1): 10

Spada J, Sander C, Burkhardt R, Häntzsch M, Mergl R, Scholz M, Hegerl U, Hensch T.
Genetic association of objective sleep phenotypes with a functional polymorphism in the neuropeptide s receptor gene. PLoS One 9(6):e98789. doi: 10.1371/journal.pone.0098789

Then FS, Luck T, Luppa M, Arélin K, Schroeter ML, Engel C, Löffler M, Thiery J, Villringer A, Riedel-Heller SG.
Association between mental demands at work and cognitive functioning in the general population - results of the health study of the Leipzig research center for civilization diseases (LIFE). J Occup Med Toxicol. (9) 23 doi: 10.1186/1745-6673-9-23

Then FS, Luck L, Luppa M, Thinschmidt M, Deckert S, Nieuwenhuijsen K, Seidler A, Riedel-Heller SG. 
Systematic review of the effect of the psychosocial working environment on cognition and dementia. Occup Environ Med 71: 358 - 365.

Walton E, Liu J, Hass J, White T, Scholz M, Roessner V, et al. 
MB-COMT promoter DNA methylation is associated with working-memory processing in schizophrenia patients and healthy controls. Epigenetics 9 (8) 1101–1107. DOI: 10.4161/epi.29223.

Wirth H, Cakir V, Hopp L, Binder H.
Analysis of miRNA expression using machine learning. Meth Mol Biol 1107:257-278 doi: 10.1007/978-1-62703-748-8_16

Zander J, Bruegel M, Kleinhempel A, Becker S, Petros S, Kortz L, Dorow J, Kratzsch J, Baber R, Ceglarek U, Thiery J, Teupser D.
Effect of biobanking conditions on short-term stability of biomarkers in human serum and plasma. Clin Chem Lab Med 52(5): 629-639
De Gruyter

Xu LX, Holland H, Kirsten H, Ahnert P, Krupp W, Bauer M, et al. 
Three gangliogliomas: Results of GTG-banding, SKY, genome-wide high resolution SNP-array, gene expression and review of the literature. Neuropathology DOI: 10.1111/neup.12176.

  • Probandengesuch LIFE-Child

    Das LIFE-Team möchte Kinder im Alter von 0 bis 18 Jahren und deren Eltern in die LIFE-Child-Studienambulanz einladen. Besuchen Sie uns und melden Sie sich an! [mehr]

  • Pressemeldungen / News

    Freistaat fördert Long-Covid-Studie der Unimedizin Leipzig
    [ext. Link sachsen.de]

    Juli 2021
    Digitale Lange Nacht der Wissenschaften 2021: LIFE ist dabei!
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    April 2021
    LIFE-Tag am 23.04.2021
    [Hier können Sie das Programm downloaden]

    Gerätetechnische Modernisierung in der Leipzig Medical Biobank abgeschlossen 
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    Bundesministerium für Bildung und Forschung fördert German Biobank Node für weitere drei Jahre
    [ext. Link bbmri.de]

    Erste Ergebnisse der NAKO-Gesundheitsstudie: COVID-19-Pandemie verändert die subjektive Gesundheit
    [ext. Link aerzteblatt.de]

    November 2020
    Klinische Studie SHAPE stärkt den Standort der Leipzig Medical Biobank 
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    September 2020
    German Biobank Alliance: Steering Committee trifft sich in Leipzig 
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