LIFE Health Study

Publications 2013

Alexandrov LB, Nik-Zainal S, Wedge DC, Aparicio SA, Behjati S, Biankin AV, Bignell GR, Bolli N, Borg A, Børresen-Dale AL, Boyault S, Burkhardt B, Butler AP, Caldas C, Davies HR, Desmedt C, Eils R, Eyfjörd JE, Foekens JA, Greaves M, Hosoda F, Hutter B, Ilicic T, Imbeaud S, Imielinski M, Jäger N, Jones DT, Jones D, Knappskog S, Kool M, Lakhani SR, López-Otín C, Martin S, Munshi NC, Nakamura H, Northcott PA, Pajic M, Papaemmanuil E, Paradiso A, Pearson JV, Puente XS, Raine K, Ramakrishna M, Richardson AL, Richter J, Rosenstiel P, Schlesner M, Schumacher TN, Span PN, Teague JW, Totoki Y, Tutt AN, Valdés-Mas R, van Buuren MM, van 't Veer L, Vincent-Salomon A, Waddell N, Yates LR, Australian Pancreatic Cancer Genome Initiative, ICGC Breast Cancer Consortium, ICGC MMML-Seq Consortium, ICGC PedBrain, Zucman-Rossi J, Futreal PA, McDermott U, Lichter P, Meyerson M, Grimmond SM, Siebert R, Campo E, Shibata T, Pfister SM, Campbell PJ, Stratton MR.
Signatures of mutational processes in human cancer. Nature 500(7463):415-21. doi: 10.1038/nature12477

Amemiya CT, … Hoffmann S,…. Stadler PF,…..et al.
The African coelacanth genome provides insights into tetrapod evolution. Nature 496(7445):311-6

Benz C, Retzbach H, Belder D.
Protein–protein interaction analysis in single microfluidic droplets using FRET and fluorescence lifetime detection. Lab Chip DOI: 10.1039/C3LC00057E

Binder H, Steiner L, Przybilla J, Rohlf T, Prohaska S, Galle J.
Transcriptional regulation by histone modifications: towards a theory of chromatin re-organization during stem cell differentiation. Phys Biol doi: 10.1088/1478-3975/10/2/026006

Breitfeld J, Heiker JT, Böttcher Y, Schleinitz D, Tönjes A, Weidle K, Krause K, Kuettner EB, Scholz M, Kiess W, Sträter N, Beck-Sickinger AG, Stumvoll M, Körner A, Blüher M, Kovacs P. 
Analysis of a rare functional truncating mutation rs61757459 in vaspin (SERPINA12) on circulating vaspin levels. J Mol Med 91(11):1285-1292

Ceglarek U., Dittrich J, Becker S, Baumann F, Kortz L, Thiery J.
Quantification of seven apolipoproteins in human plasma by proteotypic peptides using fast LC-MS/MS. Proteomics Clin Appl. 11-12: 794-801 (Epub 2013 Okt 31)

Doose G, Alexis M, Kirsch R, Findeiß S, Langenberger D, Machné R, Mörl M, Hoffmann S, Stadler PF.
Mapping the RNA-Seq trash bin: Unusual transcripts in prokaryotic transcriptome sequencing data. RNA Biol. 10(7): 1204-1210 (Epub 2013 Mai 13)
Landes Bioscience

Dukart J, Kherif F, Mueller K, Adaszewski S, Schroeter ML, Frackowiak RS, Draganski B.
Alzheimer's Disease Neuroimaging Initiative. Generative FDG-PET and MRI model of aging and disease progression in Alzheimer's disease. PLoS Comput Biol 9(4):e1002987

Dukart J, Mueller K, Villringer A, Kherif F, Draganski B, Frackowiak R, Schroeter ML.
Alzheimer's Disease Neuroimaging Initiative. Relationship between imaging biomarkers, age, progression and symptom severity in Alzheimer's disease. Neuroimage Clin 3:84-94

Dukart J, Perneczky R, Förster S, Barthel H, Diehl-Schmid J, Draganski B, Obrig H, Santarnecchi E, Drzezga A, Fellgiebel A, Frackowiak R, Kurz A, Müller K, Sabri O, Schroeter ML, Yakushev I.
Reference Cluster Normalization Improves Detection of Frontotemporal Lobar Degeneration by Means of FDG-PET. PlosONE 8(2): e55415

Eszlinger M, Krogdahl A, Münz S, Rehfeld C, Precht Jensen EM, Ferraz C, Bösenberg E, Drieschner N, Scholz M, Hegedüs L, Paschke R.
Impact of Molecular Screening for Point Mutations and Rearrangements in Routine Air-Dried Fine-Needle Aspiration Samples of Thyroid Nodules. Thyroid (Epub ahead of print 2013 Okt 29) 2014: 24(2):305-315

Frisch S, Dukart J, Vogt B, Horstmann A, Becker G, Villringer A, Barthel H, Sabri O, Müller K, Schroeter ML.
Dissociating Memory Networks in Early Alzheimer’s Disease and Frontotemporal Lobar egeneration – A Combined Study of Hypometabolism and Atrophy. . PlosONE 8(2): e55251

Gast MT, Tönjes A, Keller M, Horstmann A, Steinle N, Scholz M, Müller I, Villringer A, Stumvoll M, Kovacs P, Böttcher Y. 
The role of rs2237781 within GRM8 in eating behavior. Brain and Behavior 3(5): 495-502

Hasenclever D, Scholz M.
Comparing measures of association in 2x2 probability tables. Preprint: arXiv: 1302.616

Hass J, Walton E, Kirsten H, Liu J, Priebe L, Wolf C, Karbalai N, Gollub R, White T, Roessner V, Müller KU, Paus T, Smolka MN, Schumann G; IMAGEN Consortium, Scholz M, Cichon S, Calhoun V, Ehrlich S.
A Genome-Wide Association Study Suggests Novel Loci Associated with a Schizophrenia-Related Brain-Based Phenotype. PlosONE 8(6): e64872

Helmschrodt C, Becker S, Schröter J, Hecht M, Aust G, Thiery J, Ceglarek U.
Fast LC–MS/MS analysis of free oxysterols derived from reactive oxygen species in human plasma and carotid plaque. Clin Chim Acta. 425:3-8

Helmschrodt C, Becker S, Thiery J, Ceglarek U.
Preanalytical standardization for reactive oxygen species derived oxysterol analysis in human plasma by liquid chromatography–tandem mass spectrometry. Biochem Biophys Res Co (Epub ahead of print)

Holdt LM, von Delft A, Nicolaou A, Baumann S, Kostrzewa M, Thiery T, Teupser D. 
Quantitative Trait Loci Mapping of the Mouse Plasma Proteome (pQTL). Genetics 193, 601–608

Holdt LM, Hoffmann S, Sass K, Langenberger D, Scholz M, Krohn K, Finstermeier K, Stahringer A, Wilfert W, Beutner F, Gielen S, Schuler G, Gäbel G, Bergert H, Bechmann I, Stadler PF, Thiery J, Teupser D.
Alu Elements in ANRIL Non-Coding RNA at Chromosome9p21 Modulate Atherogenic Cell Functions throughTrans-Regulation of Gene Networks. PLOS Genetics 9 (7) e1003588

Holiga Š, Mueller K, Möller HE, Sieger T, Schroeter ML, Vymazal J, Růžička E, Jech R. 
Motor matters: tackling heterogeneity of Parkinson's disease in functional MRI studies. PlosONE 8(2):e56133

Holland H, Xu LX, Ahnert P, Kirsten H, Koschny R, Bauer M, Schober R, Meixensberger J, Krupp W. 
Comprehensive high-resolution genomic profiling and cytogenetics of two pediatric and one adult medulloblastoma. Pathol Res Pract 209(9):541-547

Holmes MV, ... Holdt LM, Beutner F, ... Teupser D, ... et al. 
Secretory Phospholipase A2-IIA and Cardiovascular Disease: a Mendelian randomization study. J Am Coll Cardiol. 62(21): 1966-1976 (Epub 2013 Juli 31)

Hopp L, Lembcke K, Binder H, Wirth H.
Portraying the Expression Landscapes of B-Cell Lymphoma-Intuitive Detection of Outlier Samples and of Molecular Subtypes. Biology 2(4):1411-1437

Hopp L, Wirth H, Fasold M, Binder H.
Portraying the expression landscapes of cancer subtypes: A case study of glioblastoma multiforme and prostate cancer. Systems Biomedicine 1(2):10 – 19

Jech R, Mueller K, Schroeter ML, Ruzicka E.
Levodopa increases functional connectivity in the cerebellum and brainstem in Parkinson’s disease. Brain doi: 10.1093/brain/awt015 (Epub Jan 30)

Keller M, Schleinitz D, Müller I, Stumvoll M, Kovacs P, Blüher M, Böttcher Y.
Global methylation level in human adipose tissue is related to fat distribution. Diabetologie und Stoffwechsel Thieme DOI: 10.1055/s-00000134

Kortz L, Dorow J, Becker S, Thiery J, Ceglarek U.
Fast liquid chromatography–quadrupole linear ion trap-mass spectrometry analysis of polyunsaturated fatty acids and eicosanoids in human plasma. J Chromatogr B

Krinner A, Roeder I, Loeffler M, Scholz M.
Merging concepts - coupling an agent-based model of hematopoietic stem cells with an ODE model of granulopoiesis. BMC Syst Biol 7(1):117 doi: 10.1186/1752-0509-7-11

Langenberger D, Çakir MV, Hoffmann S, Stadler PF.
Dicerprocessed small RNAs: Rules and exceptions. J. Exp. Zool. (Mol. Dev. Evol.) 320B:35–46

Larsen PS, …, Kiess W, ... et al.
Pregnancy and Birth Cohort Resources in Europe: a Large Opportunity for Aetiological Child Health Research. Paediatr Perinat Epidemiol. 27: 393-414

Li Y, Podlevsky JD, Marz M, Qi X, Hoffmann S, Stadler PF, Chen JJ.
Identification of purple sea urchin telomerase RNA using a next-generation sequencing based approach. RNA 19(6):852-60

Luck T, Motzek T, Luppa M, Matschinger H, Fleischer S, Sesselmann Y, Roling G, Beutner K, König HH, Behrens J, Riedel-Heller SG. 
Effectiveness of preventive home visits in reducing the risk of falls in old age: a randomized controlled trial. Clin Interv Aging. 8:697-702.

Luppa M, Luck T, Ritschel F, Angermeyer MC, Villringer A, Riedel-Heller SG. 
Depression and incident dementia. An 8-year population-based prospective study. PlosONE 8(3):e59246.

Mueller K, Jech R, Schroeter ML.
Deep-Brain Stimulation for Parkinson's Disease. New Engl J Med 368 (5): 482-483

Nitsche A, Doose G, Tafer H, Robinson M, Saha NR, Gerdol M, Canapa A, Hoffmann S, Amemiya CT, Stadler PF.
Atypical RNAs in the coelacanth transcriptome. J. Exp. Zool. (Mol. Dev. Evol.) 9999B:1-10 

Pierzchalski A, Mittag A, Bocsi J, Tarnok A.
An Innovative Cascade System for Simultaneous Separation of Multiple Cell Types. PlosONE 8(9): e74745

Polyakova M, Sonnabend N, Sander C, Mergl R, Schroeter ML.
Prevalence of minor depression in elderly persons with and without mild cognitive impairment: A systematic review. J Affect Disord (Epub ahead of print 2013 Sept 25) 2014:152-154:28-38

Raschpichler M, Kees S, Schroeter ML, Arelin K, Schlögl H, Fritzsch D, Mende M, Pampel A, Böttcher Y, Stumvoll M, Villringer A, Müller K.
Abdominal fat distribution and its relationship to brain changes - the differential effects of age on cerebellar structure and function. BMJopen doi: 10.1136/bmjopen-2012-001915

Reiprich M, Rudzok S, Schütze N, Simon JC, Lehmann I, Trump S, Polte T.
Inhibition of endotoxin-induced perinatal asthma protection by pollutants in an experimental mouse model. AllergyInhibition of endotoxin-induced perinatal asthma protection by pollutants in an experimental mouse model. Allergy 68(4): 481-489 (Epub Feb 15)

Roesch K, Hasenclever D, Scholz M.
Modelling Lymphoma Therapy and Outcome. Bull Math Biol. doi: 10.1007/s11538-013-9925-3 2014: 76: 401-430

Scheibe, P, Lazareva A, Braumann UD, Reichenbach A, Wiedemann P, Francke M, Rauscher FG.
Parametric Model for the 3D Reconstruction of Individual Fovea Shape from OCT Data. Experimental Eye Research 119 C:19-26

Schirm S, Engel C, Loeffler M, Scholz M.
A Biomathematical Model of Human Erythropoiesis under Erythropoietin and Chemotherapy Administration. PLoS ONE 8(6): e65630 

Schmid GL, Kässner F, Uhlig HH, Körner A, Kratzsch J, Händel N, Zepp FP, Kowalzik F, Laner A, Starke S, Wilhelm FK, Schuster S, Viehweger A, Hirsch W, Kiess W, Garten A. 
Sirolimus treatment of severe PTEN hamartoma tumor syndrome: case report and in vitro studies. Pediatr Res doi: 10.1038/pr.2013.246 (Epub ahead of print 2013 Dez 23) 2014: 75(4):527-534

Schroeter ML, Sacher J, Steiner J, Schoenknecht P, Mueller K.
Serum S100B Represents a New Biomarker for Mood Disorders. Curr Drug Targets 14(11): 1237-1248

Spinnler R, Gorski T, Stolz K, Schuster S, Garten A, Beck-Sickinger AG, Engelse MA, de Koning EJ, Körner A, Kiess W, Maedler K.
The adipocytokine Nampt and its product NMN have no effect on beta-cell survival but potentiate glucose stimulated insulin secretion. PlosONE 8(1) e54106

Stadler SC, Vincent CT, Fedorov VD, Patsialou A, Cherrington BD, Wakshlag JJ, Mohanan S, Zee BM, Zhang X, Garcia BA, Condeelis JS, Brown AM, Coonrod SA, Allis CD. 
Dysregulation of PAD4-mediated citrullination of nuclear GSK3β activates TGF-β signaling and induces epithelial-to-mesenchymal transition in breast cancer cells. Proc Natl Acad Sci U S A 110(29):11851-11856

Streitbürger DP, Pampel A, Krueger G, Lepsien J, Schroeter ML, Mueller K, Möller HE.
Impact of image acquisition on voxel-based-morphometry investigations of age-related structural brain changes. Neuroimage (Epub 2013) 2014 Feb 15;87:170-82. doi: 10.1016/j.neuroimage.2013.10.051

Teren A, Beutner F, Wirkner K, Loeffler M, Scholz M.
Validity, intra- and inter-observer reliability of automated devices for the assessment of ankle brachial index using photo-plethysmography. BMC Cardiovasc Disord 13:81 doi: 10.1186/1471-2261-13-81

Then FS, Luck T, Jacobi F, Berger K, Weyerer S, Grabe HJ, Busch MA, Wagner M, Riedel-Heller SG. 
[Assessment of mild cognitive impairment and dementia in epidemiologic studies. An overview on the current state of research in Germany]. Psychiatr Prax. 40(4):183-91

Then FS, Luck T, Luppa M, Thinschmidt M, Deckert S, Nieuwenhuijsen K, Seidler A, Riedel-Heller SG. 
Systematic review of the effect of the psychosocial working environment on cognition and dementia. Occup Environ Med (Epub ahead of print 2013 Nov 20) 2014: 71(5):358-365 doi: 10.1136/oemed-2013-101760

Then FS, Luppa M, Schroeter ML, König HH, Angermeyer MC, Riedel-Heller SG. 
Enriched environment at work and the incidence of dementia: results of the Leipzig longitudinal study of the aged (LEILA 75+). PlosONE 8(7):e70906.

Thomas S, Kratzsch D, Schaab M, Scholz M, Grunewald S, Thiery J, Paasch U, Kratzsch J.
Seminal plasma adipokine levels are correlated with functional characteristics of spermatozoa. Fertil Steril 99(5):1256-1263

Tomm JM, van Do T, Jende C, Simon JC, Treudler R, von Bergen M, Averbeck M.
Identification of new potential allergens from Nile perch (Lates niloticus) and cod (Gadus morhua). J Investig Allergol Clin Immunol 23(3):159-167

Treudler R, Simon JC.
Allergierisiko durch zunehmende Ausbreitung der Ambrosiapflanze. Ärzteblatt Sachsen 10/2013

Wallborn T, Grafe N, Quante M, Geserick M, Casprzig N, Ludwig J, Hiemisch A, Kiess W.
Never plan a population based cohort study on a rainy Friday after a sunny Thursday. Eur J Epidemiol 28(3): 285-286 (Epub 2013 Feb 10)

Woost TB, Dukart J, Frisch S, Barthel H, Sabri O, Mueller K, Schroeter ML. 
Neural correlates of the DemTect in Alzheimer's disease and frontotemporal lobar degeneration - A combined MRI & FDG-PET study. Neuroimage Clin 2:746-758

Zeynalova S, Ziepert M, Scholz M, Schirm S, Zwick C, Pfreundschuh M, Loeffler M; German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL).
Comparison and modelling of pegylated or unpegylated G-CSF schedules in CHOP-14 regimen of elderly patients with aggressive B-cell lymphoma. Ann Hematol 92(12):1641-52

  • Probandengesuch LIFE-Child

    Das LIFE-Team möchte Kinder im Alter von 0 bis 18 Jahren und deren Eltern in die LIFE-Child-Studienambulanz einladen. Besuchen Sie uns und melden Sie sich an! [mehr]

  • Pressemeldungen / News

    Freistaat fördert Long-Covid-Studie der Unimedizin Leipzig
    [ext. Link sachsen.de]

    Juli 2021
    Digitale Lange Nacht der Wissenschaften 2021: LIFE ist dabei!
    [mehr ]

    April 2021
    LIFE-Tag am 23.04.2021
    [Hier können Sie das Programm downloaden]

    Gerätetechnische Modernisierung in der Leipzig Medical Biobank abgeschlossen 
    [mehr ]

    Bundesministerium für Bildung und Forschung fördert German Biobank Node für weitere drei Jahre
    [ext. Link bbmri.de]

    Erste Ergebnisse der NAKO-Gesundheitsstudie: COVID-19-Pandemie verändert die subjektive Gesundheit
    [ext. Link aerzteblatt.de]

    November 2020
    Klinische Studie SHAPE stärkt den Standort der Leipzig Medical Biobank 
    [mehr ]

    September 2020
    German Biobank Alliance: Steering Committee trifft sich in Leipzig 
    [mehr ]


  • Karriere

    Stellenangebote [mehr]
    Abschlussarbeiten LIFE-IT [mehr]